2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester
CAS No.:489441-69-2
Molecular Formula:C₂₈H₄₀O₃S₂Si
Molecular Weight:516.841
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

Synonyms:2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

There total 5 articles about 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 69739-34-0
t-butyldimethylsiyl triflate

: 489442-08-2
ethyl [(2E)-6-(phenylthio)methyl]hex-2-enoate

: 489441-69-2
2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

Guidance literature:: ethyl [(2E)-6-(phenylthio)methyl]hex-2-enoate; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

formaldehyd; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

t-butyldimethylsiyl triflate; With diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Further stages.;
DOI:10.1021/ol0271436

Reference yield:

: 55387-85-4
3-hydroxymethyl-4-hydroxybutanal diethyl acetal

: 489441-69-2
2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine / tetrahydrofuran / 0.17 h / 0 °C

1.2: 93 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 88 percent / aq. HCl / tetrahydrofuran / 5 h / 20 °C

3.1: 81 percent / CH₂Cl₂ / 20 °C

4.1: LHMDS; HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: tetrahydrofuran; hexane / 0.25 h / -78 °C

4.3: 97 percent / N,N-diisopropylamine / CH₂Cl₂ / 0.25 h / 20 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; tributylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; 3.1: Horner-Emmons-Wittig reaction;
DOI:10.1021/ol0271436

Reference yield:

: 14204-27-4
N-phenylthiophthalimide

: 489441-69-2
2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenylsulfanyl-5-phenylsulfanylmethyl-hex-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine / tetrahydrofuran / 0.17 h / 0 °C

1.2: 93 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 88 percent / aq. HCl / tetrahydrofuran / 5 h / 20 °C

3.1: 81 percent / CH₂Cl₂ / 20 °C

4.1: LHMDS; HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: tetrahydrofuran; hexane / 0.25 h / -78 °C

4.3: 97 percent / N,N-diisopropylamine / CH₂Cl₂ / 0.25 h / 20 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; tributylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; 3.1: Horner-Emmons-Wittig reaction;
DOI:10.1021/ol0271436