4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

Base Information

Chemical Name:4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate
CAS No.:1355679-99-0
Molecular Formula:C₇H₁₀N₂*C₂₁H₁₉FN₂O₄
Molecular Weight:504.561
Hs Code.:

Synonyms:4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

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Chemical Property of 4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

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Technology Process of 4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

There total 3 articles about 4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 110-89-4
piperidine

: 1355679-75-2
4-(dimethylamino)pyridinium 5-fluoro-1,3-bis(phenoxycarbonyl)-1H-indol-2-olate

: 1355679-99-0
4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/j.tet.2011.12.027

Reference yield:

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1355679-99-0
4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 25 - 30 °C

2: N,N-dimethyl-formamide / 0.17 h / 0 - 2 °C

3: N,N-dimethyl-formamide / 25 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.12.027

Reference yield:

: 1122-58-3
dmap

: 1355679-71-8
phenyl 5-fluoro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate

: 1355679-99-0
4-(dimethylamino)pyridinium 5-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.17 h / 0 - 2 °C

2: N,N-dimethyl-formamide / 25 °C

In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.12.027