Technology Process of benzyl [2-ethyl-1-(5-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)butyl]carbamate
There total 8 articles about benzyl [2-ethyl-1-(5-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)butyl]carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: sodium hydrogensulfite / methanol; water / 12 h / 60 °C
2.1: hydrogen bromide / 2 h / 150 °C
3.1: sodium hydroxide / 17 h / 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
4.2: 1.5 h / -78 - 20 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C
5.2: 2 h / 20 °C
6.1: trifluorormethanesulfonic acid / dichloromethane / 48 h / 20 °C
7.1: hydrazine hydrate / ethanol / 12 h / Reflux
8.1: acetic acid / ethanol / 7 h / Reflux
With
trifluorormethanesulfonic acid; hydrogen bromide; sodium hydride; hydrazine hydrate; sodium hydrogensulfite; acetic acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; mineral oil;
DOI:10.1016/j.bmc.2011.11.015
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C
1.2: 2 h / 20 °C
2.1: trifluorormethanesulfonic acid / dichloromethane / 48 h / 20 °C
3.1: hydrazine hydrate / ethanol / 12 h / Reflux
4.1: acetic acid / ethanol / 7 h / Reflux
With
trifluorormethanesulfonic acid; sodium hydride; hydrazine hydrate; acetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; mineral oil;
DOI:10.1016/j.bmc.2011.11.015