N,N-dibenzyl-4-fluorobenzenesulfonamide

Base Information

• Chemical Name: N,N-dibenzyl-4-fluorobenzenesulfonamide
• CAS No.: 117586-81-9
• Molecular Formula: C₂₀H₁₈FNO₂S
• Molecular Weight: 355.433
• Mol file: 117586-81-9.mol

Synonyms:N,N-dibenzyl-4-fluorobenzenesulfonamide

Chemical Property of N,N-dibenzyl-4-fluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dibenzyl-4-fluorobenzenesulfonamide

There total 3 articles about N,N-dibenzyl-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Fluorobenzoic acid (456-22-4) + dibenzylamine (103-49-1) → N,N-dibenzyl-4-fluorobenzenesulfonamide (117586-81-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium pyrosulfite; cucurbituril; copper(I) bromide; In neat (no solvent); at 20 ℃; for 1h; Sealed tube; Milling;

DOI:10.1039/d1cc03224k

Reference yield: 80.0%

1-Bromo-4-fluorobenzene (460-00-4) + dibenzylamine (103-49-1) → N,N-dibenzyl-4-fluorobenzenesulfonamide (117586-81-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium pyrosulfite; cucurbituril; In neat (no solvent); at 20 ℃; for 1h; Sealed tube; Milling;

DOI:10.1039/d1cc03224k

Reference yield: 71.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + dibenzylamine (103-49-1) → N,N-dibenzyl-4-fluorobenzenesulfonamide (117586-81-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/jhet.5570440614

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

dibenzylamine

4-Fluorobenzoic acid

1-Bromo-4-fluorobenzene

Refernces

• 1、 Hanke, Thomas,R?rsch, Florian,Thieme, Theresa M.,Ferreiros, Nerea,Schneider, Gisbert,Geisslinger, Gerd,Proschak, Ewgenij,Gr?sch, Sabine,Schubert-Zsilavecz, Manfred. "Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1". . p. 7874 - 7883. Retrieved 2014/01/06.