4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole

Base Information

• Chemical Name: 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole
• CAS No.: 318467-48-0
• Molecular Formula: C₂₅H₃₀N₄OS₂
• Molecular Weight: 466.671

Synonyms:4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole

Chemical Property of 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole

There total 4 articles about 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

p-methoxybenzyl chloride (824-94-2) + 4-adamantan-1-yl-5-(2,4-dimethyl-thiazol-5-yl)-2,4-dihydro-[1,2,4]triazole-3-thione (318467-37-7) → 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole (318467-48-0)

Guidance literature:

4-adamantan-1-yl-5-(2,4-dimethyl-thiazol-5-yl)-2,4-dihydro-[1,2,4]triazole-3-thione; With potassium hydroxide; In ethanol; for 0.5h;

p-methoxybenzyl chloride; In ethanol; at 20 ℃; for 12h;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield:

2,4-dimethyl-thiazole-5-carboxylic acid hydrazide (99357-25-2) → 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole (318467-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / aq. NaOH / ethanol / 24 h

2.1: 62 percent / NaHCO₃ / H₂O; dimethylformamide / 48 h / 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 55 percent / ethanol / 12 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

Reference yield:

1-adamantylisothiocyanate (4411-26-1) → 4-adamantan-1-yl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole (318467-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / aq. NaOH / ethanol / 24 h

2.1: 62 percent / NaHCO₃ / H₂O; dimethylformamide / 48 h / 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 55 percent / ethanol / 12 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

upstream raw materials:

p-methoxybenzyl chloride

4-adamantan-1-yl-5-(2,4-dimethyl-thiazol-5-yl)-2,4-dihydro-[1,2,4]triazole-3-thione

2,4-dimethyl-thiazole-5-carboxylic acid hydrazide

1-adamantylisothiocyanate

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