(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

Base Information

Chemical Name:(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol
CAS No.:1358742-31-0
Molecular Formula:C₂₁H₂₉N₃O
Molecular Weight:339.481
Hs Code.:

Synonyms:(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

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Chemical Property of (S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

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Technology Process of (S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

There total 12 articles about (S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1358742-29-6
(S)-N₁-(2-(2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)phenyl)-N₂-(3,5-dimethylphenyl)oxalamide

: 1358742-31-0
(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

Guidance literature:: (S)-N₁-(2-(2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)phenyl)-N₂-(3,5-dimethylphenyl)oxalamide; With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere; Cooling with ice; Reflux;

With water; sodium hydroxide; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.015

Reference yield: 80.0%

: 1358742-28-5
C₂₂H₂₇N₃O₃

: 1358742-31-0
(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

Guidance literature:: C₂₂H₂₇N₃O₃; With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere; Cooling with ice; Reflux;

With water; sodium hydroxide; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.015

Reference yield:

: 1018295-15-2
2-(3,5-dimethylphenylamino)-2-oxoacetic acid

: 1358742-31-0
(S)-(1-(2-(2-(3,5-dimethylphenylamino) ethylamino)phenyl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere; Molecular sieve

1.2: 0 - 20 °C / Inert atmosphere; Molecular sieve

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

2.2: Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.11.015