C₂₅H₄₂N₄O₆

Base Information

• Chemical Name: C₂₅H₄₂N₄O₆
• CAS No.: 1335122-72-9
• Molecular Formula: C₂₅H₄₂N₄O₆
• Molecular Weight: 494.632
• Mol file: 1335122-72-9.mol

Synonyms:C₂₅H₄₂N₄O₆

Chemical Property of C₂₅H₄₂N₄O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₄₂N₄O₆

There total 7 articles about C₂₅H₄₂N₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C25H40N4O8 (1186120-60-4) → C25H42N4O6 (1335122-72-9)

Guidance literature:

With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate; In methanol; for 3h; Reflux;

DOI:10.1016/j.bmc.2011.07.008

Reference yield:

tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate (1186120-57-9) → C25H42N4O6 (1335122-72-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

4: iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate / methanol / 3 h / Reflux

With sodium azide; iron(III) chloride hexahydrate; pyrographite; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.07.008

Reference yield:

tert-butyl(1S,2S)-3-azido-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate (1186120-58-0) → C25H42N4O6 (1335122-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 13 h / 0 - 20 °C

3: iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate / methanol / 3 h / Reflux

With iron(III) chloride hexahydrate; pyrographite; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2011.07.008

upstream raw materials:

C₂₅H₄₀N₄O₈

tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

tert-butyl(1S,2S)-3-azido-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

tert-butyl (1S,2S)-3-amino-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

Downstream raw materials:

C₂₅H₄₀IN₃O₆

(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-4-methylpentanamide hydrochloride