tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate
CAS No.:1519044-34-8
Molecular Formula:C₃₅H₅₄N₂O₇S₂Si₂
Molecular Weight:735.126
Hs Code.:

Synonyms:tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

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Chemical Property of tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

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Technology Process of tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

There total 7 articles about tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1519044-06-4
tert-butyl 2-(3-bromothiophene-2-sulfonamido)ethylcarbamate

: 1519044-33-7
(2-{3,4-bis[(tert-butyldimethylsilyl)oxy]phenoxy}phenyl)boronic acid

: 1519044-34-8
tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: With potassium phosphate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; for 8h; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.201400058

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1519044-34-8
tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.08 h / 0 - 20 °C

2: potassium phosphate; palladium diacetate; triphenylphosphine / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With potassium phosphate; palladium diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058

Reference yield:

: 1,2-dimethoxy-4-(2-nitrophenoxy)benzene

: 1519044-34-8
tert-butyl 2-(3-(2-(3,4-bis(tert-butyldimethylsilyloxy)phenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate; palladium 10% on activated carbon / ethanol / 5 h / 20 °C

2.1: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C

2.2: 4.5 h / 0 - 20 °C

3.1: boron tribromide / dichloromethane / 6 h / 20 °C

4.1: 1H-imidazole; dmap / dichloromethane / 3 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 4 h / -78 - 20 °C / Inert atmosphere

5.3: 20 °C

6.1: potassium phosphate; palladium diacetate; triphenylphosphine / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With 1H-imidazole; dmap; potassium phosphate; n-butyllithium; sulfuric acid; palladium 10% on activated carbon; palladium diacetate; boron tribromide; hydrazine hydrate; triphenylphosphine; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; 6.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058