8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

Base Information

Chemical Name:8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione
CAS No.:1416807-64-1
Molecular Formula:C₁₆H₂₁N₃O₃
Molecular Weight:303.361
Hs Code.:

Synonyms:8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

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Chemical Property of 8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

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Technology Process of 8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

There total 3 articles about 8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1416808-41-7
2-[2-(2,5-dimethylphenyl)acetyl]-5-methoxy[1,2,5]triazepane-1-carboxylic acid ethyl ester

: 1416807-64-1
8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

Guidance literature:: With sodium methylate; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.12.042

Reference yield:

: 55312-97-5
2-(2,5-dimethylphenyl)acetyl chloride

: 1416807-64-1
8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: sodium methylate / N,N-dimethyl-formamide / 2.5 h / 10 - 20 °C / Inert atmosphere

With dmap; sodium methylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.12.042

Reference yield:

: 1416808-40-6
5-methoxy[1,2,5]triazepane-1-carboxylic acid ethyl ester

: 55312-97-5
2-(2,5-dimethylphenyl)acetyl chloride

: 1416807-64-1
8-(2,5-dimethylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / tetrahydrofuran / 5 h / 0 - 20 °C

2: sodium methylate / N,N-dimethyl-formamide / 2.5 h / 10 - 20 °C

With dmap; sodium methylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;