55312-97-5

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Dimethylphenylacetyl chloride is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to acylate amines and alcohols, facilitating the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-Dimethylphenylacetyl chloride serves as a reagent in the production of pesticides and other crop protection agents, enhancing the effectiveness of these products through the introduction of acetyl groups to improve their stability and activity.
Used in Fine Chemicals Production:
2,5-Dimethylphenylacetyl chloride is utilized as a versatile building block in the synthesis of fine chemicals, including fragrances, dyes, and specialty chemicals, where its acetylating properties are employed to modify the structure and properties of target molecules.
Safety Considerations:
Due to its corrosive and irritating properties, 2,5-dimethylphenylacetyl chloride must be handled with care. It should only be used in well-ventilated areas, and proper personal protective equipment, including gloves, goggles, and respirators, is essential to ensure the safety of those working with 2,5-Dimethylphenylacetyl chloride.

InChI:InChI=1/C10H11ClO/c1-7-3-4-8(2)9(5-7)6-10(11)12/h3-5H,6H2,1-2H3

Upstream product

• 13612-34-5 2-(2,5-dimethylphenyl)acetic acid 
• 16213-85-7 (2,5-dimethylphenyl)acetonitrile 
• 106-42-3 para-xylene 
• 553-94-6 4-bromo-m-xylene 
• 79-04-9 chloroacetyl chloride 
• 1122-42-5 2-iodo-p-xylene 
• 95-72-7 2-chloro-1,4-dimethyl-benzene 
• 22118-09-8 2-bromoacetyl chloride 
• 824-45-3 2,5-dimethylbenzyl chloride 

Downstream Products

• 55312-92-0 (2,5-Dimethyl-phenyl)-acetic acid 6-[2-(2,5-dimethyl-phenyl)-acetoxy]-hexyl ester 
• 55312-93-1 (2,5-Dimethyl-phenyl)-acetic acid 7-[2-(2,5-dimethyl-phenyl)-acetoxy]-heptyl ester 
• 55312-94-2 (2,5-Dimethyl-phenyl)-acetic acid 8-[2-(2,5-dimethyl-phenyl)-acetoxy]-octyl ester 
• 55312-96-4 (2,5-Dimethyl-phenyl)-acetic acid 10-[2-(2,5-dimethyl-phenyl)-acetoxy]-decyl ester 
• 55312-95-3 (2,5-Dimethyl-phenyl)-acetic acid 9-[2-(2,5-dimethyl-phenyl)-acetoxy]-nonyl ester 
• 203313-47-7 methyl cis-1-[2-(2,5-dimethylphenyl)acetamido]-4-methoxycyclohexylcarboxylate 
• 1145784-79-7 methyl 4-[[2-(2,5-dimethylphenyl)acetyl]amino]-1-methoxy-piperidine-4-carboxylate 
• 1228462-85-8 N-(4-cyano-1-methoxy-piperidin-4-yl)-2-(2,5-dimethyl-phenyl)-N-hydroxy-acetamide 
• 1228462-74-5 4-{[2-(2,5-dimethyl-phenyl)-acetyl]-hydroxy-amino}-1-methoxy-piperidine-4-carboxylic acid methyl ester 
• 1229022-39-2 4-{[2-(2,5-dimethyl-phenyl)-acetyl]-methyl-amino}-1-methoxy-piperidine-4-carboxylic acid methyl ester 
• 1228462-75-6 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one 
• 1351944-90-5 3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione 
• 1384930-30-6 2-[2-(2,5-dimethylphenyl)acetylamino]-3-(1-methoxypiperidin-4-yl)propionic acid methyl ester 
• 907187-56-8 methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate 

Relevant academic research and scientific papers

Method for preparing 2, 5-dimethylphenylacetyl chloride

The invention discloses a method for preparing 2, 5-dimethylphenylacetyl chloride, and belongs to the field of pesticide intermediate synthesis. According to the method, p-xylene is used as an initialraw material, chloromethylation, cyaniding, hydrolysis and acylating chlorination are carried out, 2, 5-dimethylphenylacetyl chloride is obtained after continuous reaction without purification, the total yield of the four steps of reaction is 75%, and the product purity is greater than 99.0%. The method is simple in process and only needs to purify the final product and is low in operation cost,mild in reaction condition and high in yield and product purity and is very easy to realize industrial production.

Synthesis method and application of 1, 3-bis(2, 5-dimethylphenyl)propan-2-one

The invention discloses a synthesis method of 1, 3-bis(2, 5-dimethylphenyl)propan-2-one. The method includes: taking 2, 5-dimethylphenylacetic acid as the raw material, carrying out acylation and ethyl esterification reaction to obtain the intermediate et

Synthetic method of insecticide spirotetramat intermediate 2,5-dimethyl phenylacetyl chloride

The invention discloses a synthetic method of an insecticide spirotetramat intermediate 2,5-dimethyl phenylacetyl chloride, belonging to the field of pesticide pharmacy. The synthetic method is characterized by comprising the step of reacting 2-halogenate

Novel preparation method of spirotetramat

The invention discloses a novel preparation method of spirotetramat and belongs to the technical field of pesticide syntyesis. The key point of the technical scheme is as follows: the method is characterized by carrying out cyclization reaction via 1-amin

Preparation method and application of novel spiro compound

The invention discloses a preparation method and application of a novel spiro compound and belongs to the technical field of pesticide synthesis. Compared with the prior art, the preparation method and application have the advantage that the novel spiro c

Preparation method and application of novel spiro pesticide

The invention discloses a preparation method and application of novel spiro pesticide and belongs to the technical field of pesticide synthesis. Compared with the prior art, the preparation method andapplication have the advantage that the novel spiro pesticide is simple in synthesis method and novel in molecular structure has good killing effect on room temperature whitefly and two-spotted spider mite and is expected to be further popularized and applied.

LIGAND-ENABLED META-C-H ACTIVATION USING A TRANSIENT MEDIATOR

An alternative approach to formation of a C-C bond at a meta-position of an aromatic compound is disclosed that employs an ethylenically unsaturated bicyclic compound as a transient mediator to achieve meta-selective C-H activation with a simple and common ortho-directing group. The use of a pyridine-based ligand assists in relaying the palladium catalyst to the meta-position by the unsaturated bicyclic compound following initial ortho-C-H activation.

AGRICULTURAL CHEMICALS

The present invention relates to compounds which are of use in the field of agriculture as insecticides and acaricides. The compounds are spirofused bicyclic compounds comprising a butenolide orpyrrolone ring.The invention also relates to compositions com

The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

New drugs for neglected tropical diseases such as human African trypanosomiasis (HAT) are needed, yet drug discovery efforts are not often focused on this area due to cost. Target repurposing, achieved by the matching of essential parasite enzymes to those human enzymes that have been successfully inhibited by small molecule drugs, provides an attractive means by which new drug optimization programs can be pragmatically initiated. In this report we describe our results in repurposing an established class of human Aurora kinase inhibitors, typified by danusertib (1), which we have observed to be an inhibitor of trypanosomal Aurora kinase 1 (TbAUK1) and effective in parasite killing in vitro. Informed by homology modeling and docking, a series of analogs of 1 were prepared that explored the scope of the chemotype and provided a nearly 25-fold improvement in cellular selectivity for parasite cells over human cells.

1, 8 -DIAZASPIRO [4.5] DECANE- 2, 4 -DIONE DERIVATIVES USEFUL AS PESTICIDES

Novel compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides.