Technology Process of 2,2-dimethyl-3-oxo-3-phenylpropanenitrile
There total 37 articles about 2,2-dimethyl-3-oxo-3-phenylpropanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2-dimethylmalononitrile; phenylboronic acid;
With
[Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene;
In
1,4-dioxane;
at 80 ℃;
for 4h;
Inert atmosphere;
With
hydrogenchloride; water;
In
1,4-dioxane; tert-butyl methyl ether;
Reagent/catalyst;
Inert atmosphere;
DOI:10.1002/anie.201703471
- Guidance literature:
-
phenyl isopropyl ketone;
With
N-ethyl-N,N-diisopropylamine; 9-iodo-9-borabicyclo{3.3.1}nonane;
In
diethyl ether; hexane;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
N-cyano-N-phenyl-p-toluenesulfonamide;
In
diethyl ether; hexane;
at 20 ℃;
for 24h;
Solvent;
Inert atmosphere;
DOI:10.1002/anie.201605445
- Guidance literature:
-
2,2-dimethylmalononitrile; phenylboronic acid;
With
potassium phosphate; [Rh(OH)(cod)]2;
In
1,4-dioxane;
at 80 ℃;
for 4h;
Inert atmosphere;
With
hydrogenchloride; water;
In
1,4-dioxane; tert-butyl methyl ether;
Inert atmosphere;
DOI:10.1002/anie.201703471
