Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Base Information

Chemical Name:Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide
CAS No.:757975-90-9
Molecular Formula:C₂₈H₄₀N₄O₄
Molecular Weight:496.65
Hs Code.:

Synonyms:Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Suppliers and Price of Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

There total 7 articles about Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 757975-90-9
Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 24 h

2: 99 percent / H₂ / Pd-C / ethanol / 3 h

3: 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; Et₃N / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

: 757975-90-9
Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 24 h

2: 99 percent / H₂ / Pd-C / ethanol / 3 h

3: 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; Et₃N / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 290817-22-0
N-(morpholin-4-ylcarbonyl)-L-leucine benzyl ester

: 757975-90-9
Morpholine-4-carboxylic acid ((S)-1-{(S)-1-[(4-benzyloxy-phenylamino)-methyl]-propylcarbamoyl}-3-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd-C / ethanol / 3 h

2: 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; Et₃N / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2006.06.031