3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester
CAS No.:147471-67-8
Molecular Formula:C₂₂H₃₃NO₆
Molecular Weight:407.507
Hs Code.:

3-<i>tert</i>-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-<i>tert</i>-butyl ester

Synonyms:3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

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Chemical Property of 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

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Technology Process of 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

There total 1 articles about 3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 218943-30-7
(3S)-3-tert-butoxycarbonylamino-5-benzyloxycarbonylpentanoic acid

: 75-65-0
tert-butyl alcohol

: 147471-67-8
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol0629622

Reference yield:

: 147471-67-8
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

: 3-amino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃;
DOI:10.1021/ol0629622

Reference yield:

: 147471-67-8
3-tert-butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

: 932019-56-2
3-[5-benzyloxycarbonyl-3-(5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 0 °C

2: 65 percent / N,N-diisopropylethylamine; HATU / dimethylformamide / 39 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ol0629622