Methyl 4-[3-(dimethylamino)propoxy]benzoate

Base Information

• Chemical Name: Methyl 4-[3-(dimethylamino)propoxy]benzoate
• CAS No.: 190660-97-0
• Molecular Formula: C13H19 N O3
• Molecular Weight: 237.299
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID30594280
• Mol file: 190660-97-0.mol

Synonyms:methyl 4-[3-(dimethylamino)propoxy]benzoate;190660-97-0;Methyl 4-(3-(dimethylamino)propoxy)benzoate;Benzoic acid, 4-[3-(dimethylamino)propoxy]-, methyl ester;SCHEMBL4966044;DTXSID30594280;SRXQDDFKGDLAJM-UHFFFAOYSA-N;MFCD06203847;AKOS025393728;TS-00689;DB-065724;CS-0328424;4-(3-dimethylamino-propoxy)-benzoic acid methyl ester;methyl 4-[3-(n,n-dimethylamino)-1-propyloxy]benzoate;methyl-4-[3-(N,N-dimethylamino)-1-propyloxy]benzoate

Chemical Property of Methyl 4-[3-(dimethylamino)propoxy]benzoate

Chemical Property:

• Boiling Point: 336.0±22.0 °C(Predicted)
• PKA: 9.29±0.28(Predicted)
• PSA: 38.77000
• Density: 1.056±0.06 g/cm3(Predicted)
• LogP: 1.80370
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 237.13649347
• Heavy Atom Count: 17
• Complexity: 223

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-(3-(dimethylamino)propoxy)benzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCOC1=CC=C(C=C1)C(=O)OC

Technology Process of Methyl 4-[3-(dimethylamino)propoxy]benzoate

There total 2 articles about Methyl 4-[3-(dimethylamino)propoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-Dimethylamino-1-propanol (3179-63-3) + 4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-[3-(dimethylamino)propoxy]benzoate (190660-97-0)

Guidance literature:

With nickel(II) bromide trihydrate; N-isopropyl-N-tert-butylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; at 40 ℃; for 48h; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.9b01957

Reference yield:

3-(dimethylamino)propyl chloride hydrochloride (5407-04-5) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → methyl 4-[3-(dimethylamino)propoxy]benzoate (190660-97-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

methyl 4-[3-(dimethylamino)propoxy]benzoate (190660-97-0) → 4-[3-(N,N-dimethylamino)-1-propyloxy]benzoic acid (190660-99-2)

Guidance literature:

upstream raw materials:

3-(dimethylamino)propyl chloride hydrochloride

methyl 4-hydroxylbenzoate

3-Dimethylamino-1-propanol

4-methoxycarbonylphenyl bromide

Downstream raw materials:

4-[3-(N,N-dimethylamino)-1-propyloxy]benzoic acid

[4-[3-(dimethylamino)propoxy]phenyl]methanol