tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate

Base Information

• Chemical Name: tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate
• CAS No.: 1005415-70-2
• Molecular Formula: C₁₂H₁₂Cl₂N₂O₂
• Molecular Weight: 287.145
• Mol file: 1005415-70-2.mol

Synonyms:tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate

Chemical Property of tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate

There total 1 articles about tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H14Cl2O2 → tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate (1005415-70-2)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1039/b715803c

Reference yield: 59.0%

tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate (1005415-70-2) + ethyl 2-diazo-3-methyl-3-butenoate (126580-11-8) → 3-(tert-butyl) 1-ethyl (R)-3-(3,4-dichlorophenyl)-2-methylcyclobut-1-ene-1,3-dicarboxylate

Guidance literature:

tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate; ethyl 2-diazo-3-methyl-3-butenoate; With C₄₅H₃₈N₂O₂; In dichloromethane; at 30 ℃; for 0.0833333h; Inert atmosphere;

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; In dichloromethane; at 30 ℃; for 0.0833333h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02825

Reference yield: 30.0%

tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate (1005415-70-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → tert-butyl 2-(3,4-dichlorophenyl)-4,4,4-trifluoro-3-(trifluoromethyl)but-2-enoate

Guidance literature:

tert-butyl 2-diazo-2-(3,4-dichlorophenyl)acetate; (trifluoromethyl)trimethylsilane; With copper(l) iodide; cesium fluoride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 10h; Schlenk technique; Inert atmosphere; Molecular sieve; Sealed tube;

With potassium hydrogen difluoride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Molecular sieve; Sealed tube;

DOI:10.1002/anie.202002409