Technology Process of Z-Val-Thr(ψMe,Mepro)-OMe
There total 1 articles about Z-Val-Thr(ψMe,Mepro)-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
dichloromethane;
at 0 ℃;
for 5h;
DOI:10.1021/jo0484732
- Guidance literature:
-
With
lithium hydroxide;
In
methanol;
at 20 ℃;
for 6h;
DOI:10.1021/jo0484732
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / aq. LiOH / methanol / 6 h / 20 °C
2: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2; dimethylformamide / 0 - 20 °C
3: 100 percent / TBAF / tetrahydrofuran / 0 - 20 °C
4: 82 percent / camphorsulfonic acid / CH2Cl2 / 5 h / 0 °C
5: 99 percent / H2 / Pd/C / methanol / 5 h
6: 96 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2; dimethylformamide / 0 - 20 °C
With
4-methyl-morpholine; lithium hydroxide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732
