5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

Base Information

Chemical Name:5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride
CAS No.:95015-80-8
Molecular Formula:C₂₅H₃₅N₃O₃*ClH
Molecular Weight:462.032
Hs Code.:

Synonyms:5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

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Chemical Property of 5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

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Technology Process of 5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

There total 9 articles about 5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 95015-70-6
Z-(Me)Tyr(Bzl)-(Me)Ava-(Me)PHA

: 95015-80-8
5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; In methanol;
DOI:10.1248/cpb.32.4157

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 95015-80-8
5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaH / tetrahydrofuran

2: mixed anhydride method

3: 85 percent / hydrogen, 1 N HCl / methanol

With hydrogenchloride; hydrogen; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.32.4157

Reference yield:

: 675-20-7
piperidin-2-one

: 95015-80-8
5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / tetrahydrofuran

2: 70 percent / 6 N HCl / 6 h / 110 °C

3: 81 percent

4: mixed anhydride method

5: hydrogen

6: mixed anhydride method

7: 85 percent / hydrogen, 1 N HCl / methanol

With hydrogenchloride; hydrogen; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.32.4157