tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

Base Information

Chemical Name:tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)
CAS No.:1401111-02-1
Molecular Formula:C₂₂H₃₃N₃O₈P₂
Molecular Weight:529.467
Hs Code.:

Synonyms:tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

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Chemical Property of tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

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Technology Process of tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

There total 5 articles about tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1401111-01-0
2-((bis(diethoxyphosphoryl)methyl)amino)isonicotinic acid

: 104-94-9
4-methoxy-aniline

: 1401111-02-1
tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.07.019

Reference yield:

: 3783-38-8
methyl isonicotinate N-oxide

: 1401111-02-1
tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonylanhydride / chloroform / 5?min / 0 °C

2: chloroform / 0.5 h / 5 °C

3: trifluoroacetic acid / chloroform / 70 °C

4: toluene / 120 °C / Dean-Stark

5: lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With p-toluenesulfonylanhydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.07.019

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1401111-02-1
tetraethyl (((4-((4-methoxyphenyl)carbamoyl)pyridin-2-yl)amino)methylene)bis(phosphonate)

Guidance literature:: Multi-step reaction with 5 steps

1: chloroform / 0.5 h / 5 °C

2: trifluoroacetic acid / chloroform / 70 °C

3: toluene / 120 °C / Dean-Stark

4: lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.07.019