benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

Base Information

Chemical Name:benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid
CAS No.:1277098-56-2
Molecular Formula:C₂₀H₁₇N₃O₂S
Molecular Weight:363.44
Hs Code.:

Synonyms:benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

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Chemical Property of benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

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Technology Process of benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

There total 4 articles about benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1277098-54-0
methyl 1-benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylate

: 1277098-56-2
benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

Guidance literature:: With hydrogenchloride; water; at 60 ℃; for 5h;
DOI:10.1002/ardp.201000167

Reference yield:

: 13797-62-1
α-(2-methyl-4-thiazolyl)acetic acid

: 1277098-56-2
benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: acetic acid / 5 h / Reflux

3: hydrogenchloride; water / 5 h / 60 °C

With hydrogenchloride; dmap; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/ardp.201000167

Reference yield:

: 68502-22-7
3-amino-4-benzylamine-benzoic acid methyl ester

: 1277098-56-2
benzyl-2-[(2-methylthiazol-4-yl)methyl]-1H-benzoimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: acetic acid / 5 h / Reflux

3: hydrogenchloride; water / 5 h / 60 °C

With hydrogenchloride; dmap; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/ardp.201000167