4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Base Information

Chemical Name:4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile
CAS No.:364788-58-9
Molecular Formula:C₂₂H₁₃Cl₂N₃O₂S
Molecular Weight:454.336
Hs Code.:

Synonyms:4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Suppliers and Price of 4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

There total 7 articles about 4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364788-56-7
4-(2,4-dichloro-5-methoxyanilino)-7-[5-(1,3-dioxolan-2-yl)-thien-3-yl]-3-quinoline-carbonitrile

: 4-(2,4-dichloro-5-methoxyanilino)-7-(5-foimyl-3-thienyl)-3-quinolinecarbonitrile

: 364788-58-9
4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 364788-56-7
4-(2,4-dichloro-5-methoxyanilino)-7-[5-(1,3-dioxolan-2-yl)-thien-3-yl]-3-quinoline-carbonitrile

: 364788-58-9
4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0960-894X(02)00302-5

Reference yield:

: 98446-49-2
2,4-dichloro-5-methoxyaniline

: 364788-58-9
4-(2,4-dichloro-5-methoxyanilino)-7-(5-formyl-thien-3-yl)-3-quinolinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine*HCl / 2-ethoxy-ethanol

2: (PPh₃)2PdCl₂ / dioxane / 4.5 h / Heating

3: 1 N aq. HCl / tetrahydrofuran / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; pyridine hydrochloride; In tetrahydrofuran; 1,4-dioxane; 2-ethoxy-ethanol;
DOI:10.1016/S0960-894X(02)00302-5