(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Base Information

Chemical Name:(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine
CAS No.:178421-79-9
Molecular Formula:C₁₉H₃₂N₂O₃
Molecular Weight:336.475
Hs Code.:

Synonyms:(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Suppliers and Price of (4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

There total 6 articles about (4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 108868-54-8
(3S,4S)-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanenitrile

: 77-76-9
2,2-dimethoxy-propane

: 178421-79-9
(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 0.5h; Heating;
DOI:10.1016/0040-4020(96)00328-6

Reference yield:

: (2R,3R)-3-cyclohexyl-2,3-epoxy-1-butanol

: 178421-79-9
(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / titanium diazidodiisopropoxide / benzene / 20 - 75 °C

2: 97 percent / H₂ / 10percentPd/C / ethyl acetate / 18 h / Ambient temperature

3: 76 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

4: 97 percent / triethylamine, 4-dimethylaminopyridne / CH₂Cl₂ / -15 - 20 °C

5: 1.) tetrabutylammonium fluoride, 2.) sodium methoxide / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h

6: 80 percent / NEt₃ / tetrahydrofuran / 22 h / Ambient temperature

7: 81 percent / p-toluenesulphonic acid / benzene / 0.5 h / Heating

With 1H-imidazole; dmap; diisopropoxytitanium diazide; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; toluene-4-sulfonic acid; triethylamine; 10% palladium on active carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0040-4020(96)00328-6

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 178421-79-9
(4S,5S)-3-(tert-butoxycarbonyl)-5-cyanomethyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NEt₃ / tetrahydrofuran / 22 h / Ambient temperature

2: 81 percent / p-toluenesulphonic acid / benzene / 0.5 h / Heating

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4020(96)00328-6