Technology Process of (1S,4R)-4-(3-cyclohexyl-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalen-1-ylamine
There total 8 articles about (1S,4R)-4-(3-cyclohexyl-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalen-1-ylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,4S)-aminoN-(S)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
3-cyclohexyl-6-fluoro-[1,2,4]triazolo[4,3-a]pyridine;
In
N,N-dimethyl-formamide; mineral oil;
at 60 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / methanol / 18 h / 20 °C
2.1: potassium permanganate; magnesium sulfate monohydrate / water; acetone / 18 h / 20 °C / Cooling with ice
3.1: Noyori's catalyst; formic acid; triethylamine / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Cooling
4.1: sodium hydroxide; water / methanol / 3.5 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
5.2: 2 h / 60 °C
With
potassium permanganate; formic acid; Noyori's catalyst; magnesium sulfate monohydrate; water; sodium hydride; triethylamine; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triphenylphosphine; hexachloroethane; triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere
2.2: 2 h / 60 °C
With
hexachloroethane; sodium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
