5-HYDRAZINYL-2-METHOXYBENZOIC ACID

Base Information

• Chemical Name: 5-HYDRAZINYL-2-METHOXYBENZOIC ACID
• CAS No.: 190248-42-1
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.18
• Mol file: 190248-42-1.mol

Synonyms:Benzoicacid, 5-hydrazino-2-methoxy- (9CI)

Chemical Property of 5-HYDRAZINYL-2-METHOXYBENZOIC ACID

Chemical Property:

• PSA: 84.58000
• LogP: 1.45230

Purity/Quality:

98%min ^*data from raw suppliers

5-HYDRAZINYL-2-METHOXYBENZOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDRAZINYL-2-METHOXYBENZOIC ACID

There total 1 articles about 5-HYDRAZINYL-2-METHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-6-methoxy-benzoic acid (3403-47-2) → 3-carboxy-4-methoxyphenylhydrazine (190248-42-1)

Guidance literature:

3-amino-6-methoxy-benzoic acid; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 ℃; for 0.25h;

DOI:10.1021/jm030212h

Reference yield:

3-carboxy-4-methoxyphenylhydrazine (190248-42-1) → 1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide (637318-41-3)

Guidance literature:

Multi-step reaction with 8 steps

1: acetonitrile; H₂O / 3 h / Heating

2: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

3: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

4: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

5: NaN₃ / dimethylformamide / 6 h / 60 °C

6: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

7: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

8: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm030212h

Reference yield:

3-carboxy-4-methoxyphenylhydrazine (190248-42-1) → 2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide (637318-46-8)

Guidance literature:

Multi-step reaction with 9 steps

1: acetonitrile; H₂O / 3 h / Heating

2: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

3: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

4: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

5: NaN₃ / dimethylformamide / 6 h / 60 °C

6: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

7: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

8: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

9: SnCl₂*2H₂O / methanol / 18 h / 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm030212h

upstream raw materials:

3-amino-6-methoxy-benzoic acid

Downstream raw materials:

ethyl 1-(3-hydroxymethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate

1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

2-(3-azidomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Refernces