Technology Process of 2-(4-Fluoro-phenyl)-3-((E)-2-iodo-vinyl)-4-isopropyl-6-phenyl-pyridine
There total 9 articles about 2-(4-Fluoro-phenyl)-3-((E)-2-iodo-vinyl)-4-isopropyl-6-phenyl-pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: EtONa / ethanol / 4.5 h / Ambient temperature
2: NH4OAc, Cu(OAc)2 / acetic acid / 24 h / Heating
3: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
4: Dess-Martin periodinane, tert-butyl alcohol / CH2Cl2 / 0.5 h / Ambient temperature
5: triphenylphosphine / CH2Cl2 / 0.42 h / Ambient temperature
6: n-BuLi / tetrahydrofuran / 1 h / -78 °C
7: 1.) AIBN, tri-n-butyltin hydride, 2.) I2 / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et2O, RT, 45 min
With
lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; iodine; tri-n-butyl-tin hydride; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: EtONa / ethanol / 4.5 h / Ambient temperature
2: NH4OAc, Cu(OAc)2 / acetic acid / 24 h / Heating
3: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
4: Dess-Martin periodinane, tert-butyl alcohol / CH2Cl2 / 0.5 h / Ambient temperature
5: triphenylphosphine / CH2Cl2 / 0.42 h / Ambient temperature
6: n-BuLi / tetrahydrofuran / 1 h / -78 °C
7: 1.) AIBN, tri-n-butyltin hydride, 2.) I2 / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et2O, RT, 45 min
With
lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; iodine; tri-n-butyl-tin hydride; sodium ethanolate; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Dess-Martin periodinane, tert-butyl alcohol / CH2Cl2 / 0.5 h / Ambient temperature
2: triphenylphosphine / CH2Cl2 / 0.42 h / Ambient temperature
3: n-BuLi / tetrahydrofuran / 1 h / -78 °C
4: 1.) AIBN, tri-n-butyltin hydride, 2.) I2 / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et2O, RT, 45 min
With
n-butyllithium; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; Dess-Martin periodane; triphenylphosphine; tert-butyl alcohol;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00113a019
