3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Name:3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CAS No.:1268476-44-3
Molecular Formula:C₂₈H₃₄N₄O₅
Molecular Weight:506.602
Hs Code.:

Synonyms:3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Property of 3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Technology Process of 3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

There total 10 articles about 3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 2-(4-aminopiperidin-1-yl)-2-oxoethanol hydrochloride

: 1268476-87-4
3,6-diethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]-pyridine-2-carboxylic acid

: 1268476-44-3
3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 20h;

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 1268476-44-3
3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: ammonium acetate / methanol / 72 h / 10 - 35 °C

2: sodium ethanolate / ethanol / 15 h / 150 °C

3: trichlorophosphate / 0.5 h / 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

5: triethylamine / ethanol / 25 h / 80 - 100 °C

6: pyridine / 3 h / 60 °C / Inert atmosphere

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 3 h / 100 °C / Inert atmosphere

8: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 10 - 35 °C

9: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 10 - 35 °C

10: sodium hydroxide; water / ethanol / 3 h / 70 °C

11: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 10 - 35 °C

With pyridine; tetrapropylammonium perruthennate; ammonium acetate; water; hydrogen; sodium ethanolate; potassium carbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 125604-20-8
ethyl 6-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1268476-44-3
3,6-diethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: trichlorophosphate / 0.5 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

3: triethylamine / ethanol / 25 h / 80 - 100 °C

4: pyridine / 3 h / 60 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 3 h / 100 °C / Inert atmosphere

6: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 10 - 35 °C

7: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 10 - 35 °C

8: sodium hydroxide; water / ethanol / 3 h / 70 °C

9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 10 - 35 °C

With pyridine; tetrapropylammonium perruthennate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;