2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

Base Information

Chemical Name:2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole
CAS No.:278183-97-4
Molecular Formula:C₁₇H₂₀N₂O₂
Molecular Weight:284.358
Hs Code.:

Synonyms:2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

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Chemical Property of 2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

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Technology Process of 2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

There total 1 articles about 2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 278184-08-0
C₁₇H₁₉N₂O₂

: 278183-97-4
2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

Guidance literature:: With hydrazine hydrate; In methanol; at 20 ℃;
DOI:10.1007/bf02499075

Reference yield:

: 278183-97-4
2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

: 3-hydroxy-2,2,4,4-tetramethyl-6-(4'-vinylbenzoyl)perhydroazirino[1,2-c]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: MnO₂

2: 15 percent / 15 percent NaOH / methanol / 6 h / 70 °C

3: H₂ / Pd/C / ethyl acetate / 20 °C

With manganese(IV) oxide; sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; 1: Oxidation / 2: Ring cleavage / 3: Catalytic hydrogenation;
DOI:10.1007/bf02499075

Reference yield:

: 278183-97-4
2-(4'-ethynylphenyl)-5-hydroxy-4,4,6,6-tetramethyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole

: 278183-99-6
6-(4'-ethynylbenzoyl)-2,2,4,4-tetramethylperhydroazirino[1,2-c]imidazole-3-oxyl

Guidance literature:: Multi-step reaction with 2 steps

1: MnO₂

2: 15 percent / 15 percent NaOH / methanol / 6 h / 70 °C

With manganese(IV) oxide; sodium hydroxide; In methanol; 1: Oxidation / 2: Ring cleavage;
DOI:10.1007/bf02499075