1-Piperidinecarboxylic acid, 4-oxo-, 1-methylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-oxo-, 1-methylethyl ester
• CAS No.: 190013-27-5
• Molecular Formula: C9H15 N O3
• Molecular Weight: 185.223
• Mol file: 190013-27-5.mol

Synonyms:4-Oxopiperidine-1-carboxylicacid isopropyl ester; Isopropyl 4-oxopiperidine-1-carboxylate

Chemical Property of 1-Piperidinecarboxylic acid, 4-oxo-, 1-methylethyl ester

Chemical Property:

• PSA: 46.61000
• LogP: 1.13420

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-oxo-, 1-methylethyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 4-oxo-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-piperidone hydrochloride (41979-39-9) + isopropyl chloroformate (108-23-6) → 4-Oxo-piperidine-1-carboxylic acid isopropyl ester (190013-27-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid isopropyl ester (1209007-75-9) → 4-Oxo-piperidine-1-carboxylic acid isopropyl ester (190013-27-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + isopropyl chloroformate (108-23-6) → 4-Oxo-piperidine-1-carboxylic acid isopropyl ester (190013-27-5)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18.16h;

isopropyl chloroformate; With triethylamine; In dichloromethane; toluene; at 20 ℃; for 2.08h;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

isopropyl chloroformate

4-piperidone hydrochloride

4,4-ethylenedioxy-piperidine

Downstream raw materials:

isopropyl 4-(6-(benzyloxy)-5-(hydroxymethyl)pyrimidin-4-yl)-4-hydroxypiperidine-1-carboxylate

isopropyl 4-(benzyloxy)-5H-spiro[furo[3,4-d]pyrimidine-7,4'-piperidine]-1'-carboxylate

C₂₁H₂₇FN₄O₄S