4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 190001-40-2
• Molecular Formula: C11H19 Cl N2 O3
• Molecular Weight: 262.736
• Hs Code.: 2933599090
• Mol file: 190001-40-2.mol

Synonyms:1-Piperazinecarboxylicacid, 4-(chloroacetyl)-, 1,1-dimethylethyl ester (9CI); 1-(2-Chloroacetyl)-4-tert-butoxycarbonylpiperazine;1-(tert-Butyloxycarbonyl)-4-chloroacetylpiperazine;1-Chloroacetyl-4-tert-butoxycarbonylpiperazine;2-Chloro-1-[4-(tert-butoxycarbonyl)piperazin-1-yl]ethanone;4-(2-Chloroacetyl)piperazine-1-carboxylic acid tert-butyl ester;4-Chloroacetylpiperazine-1-carboxylic acid tert-butyl ester; tert-Butyl4-(chloroacetyl)piperazine-1-carboxylate

Chemical Property of 4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 5.67E-06mmHg at 25°C
• Melting Point: 99-100°C
• Refractive Index: 1.501
• Boiling Point: 379.9°Cat760mmHg
• Flash Point: 183.6°C
• PSA: 49.85000
• Density: 1.203g/cm³
• LogP: 1.18030

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-(2-chloroacetyl)piperazine-1-carboxylate 98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 6 articles about 4-CHLOROACETYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloroacetyl chloride (79-04-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate (190001-40-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 21h;

Reference yield: 92.0%

diisopropylethyl amine (861359-74-2) + chloroacetyl chloride (79-04-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate (190001-40-2)

Guidance literature:

In tetrahydrofuran;

Reference yield: 88.0%

1-(1,1-dimethylethoxycarbonyl)piperazine hydrochloride + chloroacetyl chloride (79-04-9) → tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate (190001-40-2)

Guidance literature:

1-(1,1-dimethylethoxycarbonyl)piperazine hydrochloride; With potassium carbonate; In water;

chloroacetyl chloride; In dichloromethane; water; at 0 - 20 ℃; for 2.33333h;

DOI:10.1021/acs.jmedchem.1c00913

upstream raw materials:

chloroacetyl chloride

1-t-Butoxycarbonylpiperazine

diisopropylethyl amine

di-tert-butyl dicarbonate

Downstream raw materials:

4-{[2-(3-ethoxycarbonylmethoxy-4-methoxy-phenyl)-5-hydroxy-4-oxo-4H-chromen-7-yloxy]-acetyl}-piperazine-1-carboxylic acid tert-butyl ester

4-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-acetyl)-piperazine-1-carboxylic acid tert-butyl ester