4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide
CAS No.:1355487-52-3
Molecular Formula:C₁₇H₁₄ClF₅N₂O₅S
Molecular Weight:488.82
Hs Code.:

Synonyms:4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

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Chemical Property of 4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

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Technology Process of 4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

There total 3 articles about 4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1355067-70-7
5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-ol

: 1355070-71-1
4-(Bromomethyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

: 1355487-52-3
4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: 5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-ol; With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-(Bromomethyl)-2,5-difluoro-N-(methylsulfonyl)benzamide; In dimethyl sulfoxide; at 20 ℃; for 120h; Inert atmosphere;

With hydrogenchloride; In water; dimethyl sulfoxide;

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 1355487-52-3
4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate / 18 h / Reflux; Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux; light from a lamp

3.1: potassium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

3.2: 120 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1355070-69-7
2,5-difluoro-4-methyl-N-(methylsulfonyl)benzamide

: 1355487-52-3
4-({[5-chloro-6-(3,3,3-trifluoropropoxy)pyridin-3-yl]oxy}methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux; light from a lamp

2.1: potassium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 120 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In dimethyl sulfoxide; 1,2-dichloro-ethane;