5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

Base Information

Chemical Name:5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine
CAS No.:153865-93-1
Molecular Formula:C₃₅H₃₂N₂O₈
Molecular Weight:608.648
Hs Code.:

Synonyms:5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

Chemical Property:

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Technology Process of 5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

There total 1 articles about 5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31356-86-2
1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil

: 139416-71-0
1-(o-tolyl)prop-2-yn-1-ol

: 153865-93-1
5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

Guidance literature:: With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine; Yield given. Multistep reaction; 1) DMF, 15 min; 2) DMF, 50 deg C, 5 h;
DOI:10.1039/P19930002657

Reference yield: 90.0%

: 153865-93-1
5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

: 153865-94-2
3',5'-di-O-(p-toluoyl)-5-(o-toluoylethynyl)-2'-deoxyuridine

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1039/P19930002657

Reference yield:

: 153865-93-1
5-<3-hydroxy-3-(o-tolyl)prop-1-ynyl>-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine

: 5-(o-toluoylethynyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

2: 82 percent / sodium methoxide / methanol / 6 h / Ambient temperature

With sodium methylate; pyridinium chlorochromate; In methanol; dichloromethane;
DOI:10.1039/P19930002657