5-Chloro-2,6-dimethoxy-4-methylquinoline

Base Information

Chemical Name:5-Chloro-2,6-dimethoxy-4-methylquinoline
CAS No.:189746-19-8
Molecular Formula:C₁₂H₁₂ClNO₂
Molecular Weight:237.686
Hs Code.:
European Community (EC) Number:629-908-0
DSSTox Substance ID:DTXSID90593451
Wikidata:Q82487940
Mol file:189746-19-8.mol

Synonyms:5-CHLORO-2,6-DIMETHOXY-4-METHYLQUINOLINE;189746-19-8;Quinoline,5-chloro-2,6-dimethoxy-4-methyl-;2,6-dimethoxy-5-chloro-4-methylquinoline;SCHEMBL7519858;DTXSID90593451;JDXORUMZWYWTTK-UHFFFAOYSA-N;SB17836;DA-37588;CS-0449107

Suppliers and Price of 5-Chloro-2,6-dimethoxy-4-methylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 5-Chloro-2,6-dimethoxy-4-methylquinoline

Chemical Property:

PSA：31.35000
LogP:3.21380
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:237.0556563
Heavy Atom Count:16
Complexity:239

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC2=C1C(=C(C=C2)OC)Cl)OC

Technology Process of 5-Chloro-2,6-dimethoxy-4-methylquinoline

There total 2 articles about 5-Chloro-2,6-dimethoxy-4-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 189746-20-1
2,6-dimethoxy-4-methyl-quinoline

: 189746-19-8
5-chloro-2,6-dimethoxy-4-methyl-quinoline

Guidance literature:: With sulfuryl dichloride; In acetic acid; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm100911f

Reference yield:

: 6340-55-2
2-chloro-4-methyl-6-methoxyquinoline

: 189746-19-8
5-chloro-2,6-dimethoxy-4-methyl-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 43 h / Reflux; Inert atmosphere

2: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere

With sulfuryl dichloride; In methanol; acetic acid;
DOI:10.1021/jm100911f

Reference yield:

: 189746-19-8
5-chloro-2,6-dimethoxy-4-methyl-quinoline

: 1260253-47-1
8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenyl)-quinoline succinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentoxide / triethyl phosphate / 1 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 35 °C / Reflux; Inert atmosphere

2.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux

3.1: 10% palladium on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr / Inert atmosphere

4.1: diisopropylamine / 1-methyl-pyrrolidin-2-one / 80 °C / Inert atmosphere

5.1: hydrazine hydrate / ethanol / Reflux; Inert atmosphere

5.2: Inert atmosphere

With phosphorus pentoxide; 10% palladium on activated carbon; tetrabutylammomium bromide; hydrogen; palladium diacetate; sodium carbonate; hydrazine hydrate; diisopropylamine; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; triethyl phosphate; ethanol; water; 2.1: Suzuki coupling;
DOI:10.1021/jm100911f