Technology Process of 5-CHLORO-2,6-DIMETHOXY-4-METHYLQUINOLINE
There total 2 articles about 5-CHLORO-2,6-DIMETHOXY-4-METHYLQUINOLINE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuryl dichloride;
In
acetic acid;
at 60 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jm100911f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanol / 43 h / Reflux; Inert atmosphere
2: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere
With
sulfuryl dichloride;
In
methanol; acetic acid;
DOI:10.1021/jm100911f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: phosphorus pentoxide / triethyl phosphate / 1 h / 20 °C / Inert atmosphere
1.2: 0.25 h / 35 °C / Reflux; Inert atmosphere
2.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
3.1: 10% palladium on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr / Inert atmosphere
4.1: diisopropylamine / 1-methyl-pyrrolidin-2-one / 80 °C / Inert atmosphere
5.1: hydrazine hydrate / ethanol / Reflux; Inert atmosphere
5.2: Inert atmosphere
With
phosphorus pentoxide; 10% palladium on activated carbon; tetrabutylammomium bromide; hydrogen; palladium diacetate; sodium carbonate; hydrazine hydrate; diisopropylamine; triphenylphosphine;
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; triethyl phosphate; ethanol; water;
2.1: Suzuki coupling;
DOI:10.1021/jm100911f
