5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline

Base Information

Chemical Name:5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline
CAS No.:189746-21-2
Molecular Formula:C12H11 Cl N2 O4
Molecular Weight:282.68
Hs Code.:
European Community (EC) Number:606-189-1
DSSTox Substance ID:DTXSID70450199
Wikidata:Q82269803
Mol file:189746-21-2.mol

Synonyms:5-CHLORO-2,6-DIMETHOXY-4-METHYL-8-NITROQUINOLINE;189746-21-2;SCHEMBL2936278;DTXSID70450199;VZVNAHCSVNVONJ-UHFFFAOYSA-N;SB17837;FT-0722745;8-Nitro-2,6-dimethoxy-5-chloro-4-methylquinoline;EN300-18787309

Suppliers and Price of 5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.618
Boiling Point:428.963°C at 760 mmHg
Flash Point:213.23°C
PSA：77.17000
Density:1.38g/cm³
LogP:3.64520
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:282.0407345
Heavy Atom Count:19
Complexity:338

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC2=C1C(=C(C=C2[N+](=O)[O-])OC)Cl)OC

Technology Process of 5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline

There total 4 articles about 5-Chloro-2,6-dimethoxy-4-methyl-8-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 189746-19-8
5-chloro-2,6-dimethoxy-4-methyl-quinoline

: 189746-21-2
5-chloro-2,6-dimethoxy-4-methyl-8-nitro-quinoline

Guidance literature:: 5-chloro-2,6-dimethoxy-4-methyl-quinoline; With phosphorus pentoxide; In triethyl phosphate; at 20 ℃; for 1h; Inert atmosphere;

With potassium nitrate; In methanol; triethyl phosphate; at 35 ℃; for 0.25h; Reflux; Inert atmosphere;
DOI:10.1021/jm100911f

Reference yield:

: 337913-25-4
phosphorus pentaoxide

: 189746-19-8
5-chloro-2,6-dimethoxy-4-methyl-quinoline

: 78-40-0
triethyl phosphate

: 110-54-3
hexane

: 189746-21-2
5-chloro-2,6-dimethoxy-4-methyl-8-nitro-quinoline

Guidance literature:: With potassium nitrate; In methanol;

Reference yield:

: 6340-55-2
2-chloro-4-methyl-6-methoxyquinoline

: 189746-21-2
5-chloro-2,6-dimethoxy-4-methyl-8-nitro-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 43 h / Reflux; Inert atmosphere

2.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere

3.1: phosphorus pentoxide / triethyl phosphate / 1 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 35 °C / Reflux; Inert atmosphere

With sulfuryl dichloride; phosphorus pentoxide; In methanol; triethyl phosphate; acetic acid;
DOI:10.1021/jm100911f