5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

Base Information

Chemical Name:5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid
CAS No.:748109-28-6
Molecular Formula:C₃₇H₄₆N₄O₆
Molecular Weight:642.795
Hs Code.:

5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

Synonyms:5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

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Chemical Property of 5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

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Technology Process of 5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

There total 9 articles about 5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771452-47-2
5-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid benzyl ester

: 748109-28-6
5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; acetonitrile; for 24h; under 2068.6 Torr; Yield given; Ambient temperature;
DOI:10.1002/hlca.19970800421

Reference yield:

: 63649-13-8
benzyl 5-aminovalerate

: 748109-28-6
5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 380 mg / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

2: H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; palladium on activated charcoal; In dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145485-77-4
3-t-butoxy-carbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

: 748109-28-6
5-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

3: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

4: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 380 mg / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

6: H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.19970800421