5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

Base Information

Chemical Name:5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine
CAS No.:159312-15-9
Molecular Formula:C₄₀H₅₀N₂O₈Si
Molecular Weight:714.931
Hs Code.:

Synonyms:5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

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Chemical Property of 5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

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Technology Process of 5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

There total 6 articles about 5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159312-12-6
5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2',3'-secoribothymidine

: 159312-15-9
5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, Cl₂CHCOOH / dimethylsulfoxide

2: tetrahydrofuran

With dichloro-acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/0040-4020(94)00950-Y

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 159312-15-9
5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 19 percent / pyridine / Ambient temperature

2: DCC, dichloroacetic acid / dimethylsulfoxide / 2 h

3: tetrahydrofuran

With pyridine; dichloro-acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)90437-5

Reference yield:

: (R)-3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-propionaldehyde

: 159312-15-9
5'-O-(p-monomethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxy-2'-C-(E-carbethoxymethylidene)-2',3'-secoribothymidine

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / ethanol

2: 19 percent / pyridine / Ambient temperature

3: DCC, dichloroacetic acid / dimethylsulfoxide / 2 h

4: tetrahydrofuran

With pyridine; dichloro-acetic acid; sodium tetrahydroborate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)90437-5