diisopropyl 3-hydroxy-3-phenylpropanamide

Base Information

• Chemical Name: diisopropyl 3-hydroxy-3-phenylpropanamide
• CAS No.: 225943-09-9
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• Mol file: 225943-09-9.mol

Synonyms:diisopropyl 3-hydroxy-3-phenylpropanamide

Chemical Property of diisopropyl 3-hydroxy-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl 3-hydroxy-3-phenylpropanamide

There total 6 articles about diisopropyl 3-hydroxy-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diisopropyl-3-phenylpropionamide (20308-62-7) → diisopropyl 3-hydroxy-3-phenylpropanamide (225943-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS / CCl₄ / Heating; UV-irradiation

2: AgNO₃ / acetone; H₂O

With N-Bromosuccinimide; silver nitrate; In tetrachloromethane; water; acetone;

DOI:10.1021/ja011129r

Reference yield:

3-Phenylpropionic acid (501-52-0) → diisopropyl 3-hydroxy-3-phenylpropanamide (225943-09-9)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / benzene / 2 h / Heating

2: benzene / 2 h

3: NBS / CCl₄ / Heating; UV-irradiation

4: AgNO₃ / acetone; H₂O

With N-Bromosuccinimide; phosphorus pentachloride; silver nitrate; In tetrachloromethane; water; acetone; benzene;

DOI:10.1021/ja011129r

Reference yield:

diisopropyl 3-bromo-3-phenylpropanamide → diisopropyl 3-hydroxy-3-phenylpropanamide (225943-09-9)

Guidance literature:

With silver nitrate; In water; acetone;

DOI:10.1021/ja011129r

upstream raw materials:

N,N-diisopropyl-3-phenylpropionamide

hydrocinnamic acid chloride

3-Phenylpropionic acid

diisopropylamine

Downstream raw materials:

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

Refernces

• 1、 Tan, Eng Wui,Chan, Bun,Blackman, Allan G.. "A Polar Effects Controlled Enantioselective 1,2-Chlorine Atom Migration via a Chlorine-Bridged Radical Intermediate". . p. 2078 - 2079. Retrieved 2007/10/03.