6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

Base Information

Chemical Name:6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)
CAS No.:1312468-63-5
Molecular Formula:C₃₈H₅₈O₇Si
Molecular Weight:654.96
Hs Code.:

Synonyms:6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

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Chemical Property of 6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

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Technology Process of 6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

There total 4 articles about 6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312468-62-4
6β-hydroxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

: 98-88-4
benzoyl chloride

: 1312468-63-5
6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

Guidance literature:: With pyridine; at 20 ℃; for 12h;

Reference yield:

: 80-75-1,22847-91-2
11-alpha-hydroxyprogesterone

: 1312468-63-5
6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

2.1: 1H-imidazole / N,N-dimethyl-formamide / 264 h / 20 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 2 h / 4 - 20 °C / Inert atmosphere

3.2: 4 - 50 °C

4.1: pyridine / 12 h / 20 °C

With pyridine; 1H-imidazole; borane-THF; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312467-50-7
11α-O-(tert-butyl-dimethylsilanyloxy)pregn-5-en-3,20-bis-ethyleneketal

: 1312468-63-5
6β-benzoyloxy-11α-(tert-butyldimethylsilanyloxy)-5β-pregnan-3,20-bis(ethyleneketal)

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 2 h / 4 - 20 °C / Inert atmosphere

1.2: 4 - 50 °C

2.1: pyridine / 12 h / 20 °C

With pyridine; borane-THF; In tetrahydrofuran;