2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

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Chemical Name:2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide
CAS No.:1311473-37-6
Molecular Formula:C₂₆H₂₄FN₅O₄
Molecular Weight:489.506
Hs Code.:

Synonyms:2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

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Chemical Property of 2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

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Technology Process of 2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

There total 4 articles about 2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311473-36-5
3-(2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-phenylbutanoic acid

: 593-56-6
N-methoxylamine hydrochloride

: 1311473-37-6
2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

Guidance literature:: 3-(2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-phenylbutanoic acid; N-methoxylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 5 ℃; for 0.0833333h;

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 5 - 20 ℃;

Reference yield:

: 1241025-70-6
ethyl 3-amino-2-hydroxy-4-phenylbutanoate hydrochloride

: 1311473-37-6
2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 - 20 °C / pH 10

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 5 °C

3.2: 5 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1311473-35-4
2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)nicotinic acid

: 1311473-37-6
2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)-N-(3-hydroxy-4-(methoxyamino)-4-oxo-1-phenylbutan-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 - 20 °C / pH 10

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 5 °C

3.2: 5 - 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;