N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

Base Information

• Chemical Name: N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido
• CAS No.: 221658-95-3
• Molecular Formula: C₁₆H₁₇I₂N₃O₃S
• Molecular Weight: 585.204
• Mol file: 221658-95-3.mol

Synonyms:N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

Chemical Property of N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

There total 5 articles about N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetic anhydride (108-24-7) + N-2-<(2-amino-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido (221658-93-1) → N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido (221658-95-3)

Guidance literature:

In acetonitrile; benzene; for 2.5h; Heating;

DOI:10.1021/jm990012z

Reference yield:

2-[2-(2-amino-1,3-thiazol-4-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide (95914-09-3) → N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido (221658-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent aq. HBr / Heating

2: NaOH / CHCl₃ / 1.5 h / Ambient temperature

3: 92 percent / acetonitrile; benzene / 2.5 h / Heating

With sodium hydroxide; hydrogen bromide; In chloroform; acetonitrile; benzene;

DOI:10.1021/jm990012z

Reference yield:

3,5-diiodo-4-methoxyphenylacetyl chloride (221660-62-4) → N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido (221658-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / CHCl₃ / 1.5 h / Ambient temperature

2: 92 percent / acetonitrile; benzene / 2.5 h / Heating

With sodium hydroxide; In chloroform; acetonitrile; benzene;

DOI:10.1021/jm990012z

upstream raw materials:

acetic anhydride

N-2-<(2-amino-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

2-[2-(2-amino-1,3-thiazol-4-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

3,5-diiodo-4-methoxyphenylacetyl chloride

Downstream raw materials:

2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine