Technology Process of (3aRS,6RS,6aRS)-6-benzoyloxy-3,3a,4,5,6,6a-hexahydro-1,5,5-trimethylpentalene
There total 12 articles about (3aRS,6RS,6aRS)-6-benzoyloxy-3,3a,4,5,6,6a-hexahydro-1,5,5-trimethylpentalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
69478-30-4,82873-77-6,82873-80-1
(1R,3aS,6aR)-2,2,6-Trimethyl-1,2,3,3a,4,6a-hexahydro-pentalen-1-ol
- Guidance literature:
-
In
pyridine;
for 6h;
Ambient temperature;
DOI:10.1016/0040-4020(84)85126-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / Jones reagent / acetone / 0.5 h / 0 °C
2: 23.9 percent / 0.82 M AlH3 / tetrahydrofuran / 3 h / 0 °C
3: 86 percent / LiCl, methanesulfonyl chloride / dimethylformamide; various solvent(s) / 1.5 h / 0 °C
4: 8.0 g / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature
5: 95 percent / pyridine / 12 h / 0 °C
6: 82 percent / KO2 / dibenzo-18-crown-6-ether / 1,2-dimethoxy-ethane; dimethylsulfoxide / 48 h / Ambient temperature
7: 96 percent / pyridine / 6 h / Ambient temperature
With
aluminium hydride; lithium aluminium tetrahydride; jones reagent; methanesulfonyl chloride; lithium chloride;
dibenzo-18-crown-6;
In
tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4020(84)85126-1
-
-
82873-75-4
(2aRS,4aSR,6aSR,6bRS)-2a,4a,5,6,6a,6b-hexahydro-6,6-dimethyl-2H-pentaleno<1,6-bc>furan-2-one
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) t-AmONa; 2.) water / 1.) DMSO, 18 h, r.t.; 2.) 6 h; 3.) 24 h
2: 92 percent / Jones reagent / acetone / 0.5 h / 0 °C
3: 23.9 percent / 0.82 M AlH3 / tetrahydrofuran / 3 h / 0 °C
4: 86 percent / LiCl, methanesulfonyl chloride / dimethylformamide; various solvent(s) / 1.5 h / 0 °C
5: 8.0 g / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature
6: 95 percent / pyridine / 12 h / 0 °C
7: 82 percent / KO2 / dibenzo-18-crown-6-ether / 1,2-dimethoxy-ethane; dimethylsulfoxide / 48 h / Ambient temperature
8: 96 percent / pyridine / 6 h / Ambient temperature
With
aluminium hydride; lithium aluminium tetrahydride; jones reagent; water; sodium tert-pentoxide; methanesulfonyl chloride; lithium chloride;
dibenzo-18-crown-6;
In
tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4020(84)85126-1
