6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile

Base Information

Chemical Name:6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile
CAS No.:131364-37-9
Molecular Formula:C₁₂H₇Cl₂N₃OS
Molecular Weight:312.179
Hs Code.:

Synonyms:6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile

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Chemical Property of 6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile

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Technology Process of 6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile

There total 6 articles about 6-(3,4-dichlorophenyl)-4-hydroxy-2-methylthiopyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 131364-74-4
5-Cyano-6-(3,4-dichlorophenyl)-2-thiouracil

: 74-88-4
methyl iodide

: 131364-37-9
4-(3,4-dichlorophenyl)-2-methylsulfanyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 3h;
DOI:10.1002/ardp.19903231103

Reference yield: 50.0%

: 867-44-7,147895-43-0
S-Methylisothiourea sulfate

: 105-56-6
ethyl 2-cyanoacetate

: 6287-38-3
3,4-dichlorobenzaldehyde

: 131364-37-9
4-(3,4-dichlorophenyl)-2-methylsulfanyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Guidance literature:: With potassium carbonate; In ethanol; at 70 ℃; for 60h;

Reference yield: 40.0%

: 147895-43-0
S-methylisothiourea hemisulphate

: 105-56-6
ethyl 2-cyanoacetate

: 6287-38-3
3,4-dichlorobenzaldehyde

: 131364-37-9
4-(3,4-dichlorophenyl)-2-methylsulfanyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Guidance literature:: S-methylisothiourea hemisulphate; With potassium carbonate; In water; at 20 ℃; Sonication;

ethyl 2-cyanoacetate; 3,4-dichlorobenzaldehyde; In ethanol; water; at 50 ℃; for 2h; Sonication;
DOI:10.21577/0103-5053.20160289