4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

Base Information

Chemical Name:4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol
CAS No.:676348-79-1
Molecular Formula:C₂₉H₂₈F₃N₃O₂S₂
Molecular Weight:571.687
Hs Code.:

Synonyms:4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

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Chemical Property of 4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

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Technology Process of 4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

There total 8 articles about 4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 676348-78-0
4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenol

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 676348-79-1
4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

Guidance literature:: 4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenol; With N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride; In dichloromethane; at -5 - 0 ℃; for 0.666667h;

4-(4-methoxyphenyl)piperazine; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium hydroxide; water; In acetone; at 20 ℃;

Reference yield:

: methanesulfonic acid 4-[4-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenyl ester

: 676348-79-1
4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; acetone; at 20 ℃; for 1h;
DOI:10.1021/jo061295n

Reference yield:

: 444615-64-9
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4,5-diyl}dimethanol

: 676348-79-1
4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / methanesulfonic acid / acetonitrile; toluene / 17 h / 85 - 87 °C

2: ethyldiisopropylamine / CH₂Cl₂ / 5 °C

3: tetrahydrofuran / 1 h / 20 °C

4: 12.5 g / NaOH / tetrahydrofuran; acetone; H₂O / 1 h / 20 °C

With sodium hydroxide; methanesulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo061295n