(S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

Base Information

Chemical Name:(S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate
CAS No.:1333165-50-6
Molecular Formula:C₁₄H₁₅BrFNO₄S
Molecular Weight:392.246
Hs Code.:

Synonyms:(S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

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Chemical Property of (S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

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Technology Process of (S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

There total 2 articles about (S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 687-47-8
(S)-Ethyl lactate

: 1225040-03-8
4-bromo-2-fluoro-N-(prop-2-ynyl)benzenesulfonamide

: 1333165-50-6
(S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

Guidance literature:: (S)-Ethyl lactate; 4-bromo-2-fluoro-N-(prop-2-ynyl)benzenesulfonamide; With triphenylphosphine; In tetrahydrofuran; for 0.166667h;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/ol201962n

Reference yield:

: 216159-03-4
4-bromo-2-fluorobenzenesulfonyl chloride

: 1333165-50-6
(S)-ethyl 2-(4-bromo-2-fluoro-N-(prop-2-ynyl)phenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h

2.2: 12 h / 20 °C

With dmap; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1021/ol201962n