ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate

Base Information

• Chemical Name: ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate
• CAS No.: 1444001-21-1
• Molecular Formula: C₁₅H₁₈N₂O₅
• Molecular Weight: 306.318
• Mol file: 1444001-21-1.mol

Synonyms:ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate

Chemical Property of ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate

There total 2 articles about ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester (29681-78-5) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate (1444001-21-1)

Guidance literature:

3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester; With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; for 1h;

4-Fluoronitrobenzene; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

3-carboethoxy-2-pyridone (3731-16-6) → ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate (1444001-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium / 1 h / Reflux

2.1: sodium hydride / mineral oil; 1-methyl-pyrrolidin-2-one / 1 h

2.2: 18 h / 20 °C

With sodium; sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil;

DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

ethyl 3-methyl-1-(4-nitrophenyl)-2-oxopiperidine-3-carboxylate (1444001-21-1) → ethyl 1-(4-aminophenyl)-3-methyl-2-oxopiperidine-3-carboxylate (1444001-23-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr;

DOI:10.1016/j.ejmech.2013.03.056

upstream raw materials:

3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester

4-Fluoronitrobenzene

3-carboethoxy-2-pyridone

Downstream raw materials:

ethyl 1-(4-((S)-5-((1,3-dioxoisoindolin-2-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

ethyl 1-(4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

ethyl 1-(4-aminophenyl)-3-methyl-2-oxopiperidine-3-carboxylate