ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

Base Information

Chemical Name:ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate
CAS No.:268544-84-9
Molecular Formula:C₁₅H₁₅ClN₂O₄
Molecular Weight:322.748
Hs Code.:

Synonyms:ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

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Chemical Property of ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

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Technology Process of ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

There total 1 articles about ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1073-69-4
N-4-chlorophenylhydrazine

: 127107-00-0
ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentanoate

: 268544-84-9
ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

Guidance literature:: In dichloromethane; at 0 ℃;
DOI:10.1002/jhet.5570370129

Reference yield: 81.0%

: 268544-84-9
ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

: 268544-89-4
1-(4-chlorophenyl)-1-(4-methoxycarbonyl)-5-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In methanol; at 0 ℃; for 24h;
DOI:10.1002/jhet.5570370129

Reference yield:

: 268544-84-9
ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

: 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 1M aq. KOH / methanol / 24 h / 0 °C

2: PCl₅ / diethyl ether / 1 h / 0 °C

3: aq. NaHCO₃ / CHCl₃ / 4 h / 20 °C

4: 84 percent / KOH / ethanol / 1 h / Heating

With potassium hydroxide; phosphorus pentachloride; sodium hydrogencarbonate; In methanol; diethyl ether; ethanol; chloroform; 1: Hydrolysis / 2: Chlorination / 3: Acylation / 4: Hydrolysis;
DOI:10.1002/jhet.5570370129