methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

Base Information

Chemical Name:methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate
CAS No.:268544-99-6
Molecular Formula:C₁₆H₁₆ClN₃O₃
Molecular Weight:333.774
Hs Code.:

Synonyms:methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

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Chemical Property of methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

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Technology Process of methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

There total 5 articles about methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765-30-0
Cyclopropylamine

: 1026591-00-3
3-chlorocarbonyl-1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid methyl ester

: 268544-99-6
methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In chloroform; at 20 ℃; for 4h;
DOI:10.1002/jhet.5570370129

Reference yield:

: 1073-69-4
N-4-chlorophenylhydrazine

: 268544-99-6
methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / CH₂Cl₂ / 0 °C

2: 81 percent / 1M aq. KOH / methanol / 24 h / 0 °C

3: PCl₅ / diethyl ether / 1 h / 0 °C

4: aq. NaHCO₃ / CHCl₃ / 4 h / 20 °C

With potassium hydroxide; phosphorus pentachloride; sodium hydrogencarbonate; In methanol; diethyl ether; dichloromethane; chloroform; 1: cyclocondensation / 2: Hydrolysis / 3: Chlorination / 4: Acylation;
DOI:10.1002/jhet.5570370129

Reference yield:

: 127107-00-0
ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentanoate

: 268544-99-6
methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / CH₂Cl₂ / 0 °C

2: 81 percent / 1M aq. KOH / methanol / 24 h / 0 °C

3: PCl₅ / diethyl ether / 1 h / 0 °C

4: aq. NaHCO₃ / CHCl₃ / 4 h / 20 °C

With potassium hydroxide; phosphorus pentachloride; sodium hydrogencarbonate; In methanol; diethyl ether; dichloromethane; chloroform; 1: cyclocondensation / 2: Hydrolysis / 3: Chlorination / 4: Acylation;
DOI:10.1002/jhet.5570370129