2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Base Information

Chemical Name:2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide
CAS No.:519028-34-3
Molecular Formula:C₁₈H₂₁FN₄O₃
Molecular Weight:360.388
Hs Code.:

Synonyms:2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

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Chemical Property of 2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

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Technology Process of 2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

There total 7 articles about 2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-cyclohexyl}-carbamic acid benzyl ester

: 519028-34-3
2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm070027u

Reference yield:

: benzyl (1-cyanocyclohexyl)carbamate

: 519028-34-3
2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 3 h / 60 °C

3: xylene / Heating

4: methanol / Heating

5: H₂ / Pd/C / methanol / 1 h / 20 °C

With hydrogen; hydroxylamine; palladium on activated charcoal; In methanol; chloroform; xylene;
DOI:10.1021/jm070027u

Reference yield:

: 940868-37-1
benzyl {1-[amino(hydroxyimino)methyl]cyclohexyl}carbamate

: 519028-34-3
2-(1-amino-cyclohexyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid 4-fluoro-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: CHCl₃ / 3 h / 60 °C

2: xylene / Heating

3: methanol / Heating

4: H₂ / Pd/C / methanol / 1 h / 20 °C

With hydrogen; palladium on activated charcoal; In methanol; chloroform; xylene;
DOI:10.1021/jm070027u