3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

Base Information

Chemical Name:3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide
CAS No.:1332302-24-5
Molecular Formula:C₂₀H₁₇ClF₂N₆O₂
Molecular Weight:446.844
Hs Code.:

Synonyms:3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

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Chemical Property of 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

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Technology Process of 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

There total 6 articles about 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1332300-70-5
3-amino-5-fluoro-N-methylbenzamide

: 1332302-22-3
2-chloro-4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazine

: 1332302-24-5
3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80 ℃; for 24h;

Reference yield:

: 110882-60-5
3-fluoro-5-nitrobenzonitrile

: 1332302-24-5
3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid; water; sulfuric acid / 24 h / 70 °C

2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C

With sulfuric acid; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 14027-75-9
3-nitro-5-fluorobenzoic acid

: 1332302-24-5
3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C / Sealed tube

2: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;