110882-60-5

Usage

Uses

Used in Chemical Synthesis Industry:
3-Fluoro-5-Nitrobenzonitrile is used as a key intermediate in the synthesis of various organic compounds, particularly for the production of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable building block in the development of new molecules with desired properties.
Used in Research and Development:
3-Fluoro-5-Nitrobenzonitrile is employed as a research compound in academic and industrial laboratories. It is used to study the effects of fluorination and nitration on the chemical properties and reactivity of benzonitrile derivatives, contributing to the understanding of structure-property relationships in organic chemistry.
Used in Material Science:
3-Fluoro-5-Nitrobenzonitrile is used as a precursor in the development of new materials with specific properties, such as advanced polymers and composites. Its incorporation into these materials can lead to improved thermal stability, mechanical strength, or other desirable characteristics, depending on the application.

InChI:InChI=1/C7H3FN2O2/c8-6-1-5(4-9)2-7(3-6)10(11)12/h1-3H

Upstream product

• 7087-65-2 1-bromo-3-fluoro-5-nitrobenzene 
• 544-92-3 copper(I) cyanide 
• 3819-88-3 1-fluoro-3-iodo-5-nitrobenzene 
• 619-24-9 3-nitrobenzonitrile 
• 557-21-1 dicyanozinc 
• 10472-88-5 4-fluoro-2-bromo-6-nitroaniline 
• 364-78-3 2-nitro-4-fluoroaniline 
• 4110-35-4 3,5-dinitrobenzonitrile 

Downstream Products

• 210992-28-2 3-amino-5-fluoro-benzonitrile 
• 752967-51-4 3-fluoro-5-piperazin-1-yl-benzonitrile 
• 1026751-11-0 3-fluoro-5-{4-[3-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-oxo-propyl]-piperazin-1-yl}-benzonitrile 
• 108159-96-2 3-fluoro-5-nitrobenz-aldehyde 
• 1332302-24-5 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide 
• 1208075-03-9 3-fluoro-5-nitrobenzamide 
• 1332300-70-5 3-amino-5-fluoro-N-methylbenzamide 
• 1239596-39-4 3-fluoro-N-methyl-5-nitrobenzamide 
• 873697-58-6 C₁₆H₂₂FN₃O₄ 
• 1008138-56-4 3-amino-5-morpholin-4-yl-benzonitrile 
• 883987-74-4 3-fluoro-5-nitrobenzyl alcohol 
• 14027-75-9 3-nitro-5-fluorobenzoic acid 

Relevant academic research and scientific papers

Process for fluorinating inorganic or organic compounds by direct fluorination

The invention relates to the use of a fluorinated gas, wherein the elemental fluorine (F2) is present at a high concentration, the present invention relates to a process for producing fluorinated compounds by direct fluorination using a fluorination gas in which elemental fluorine (F2) is present at a high concentration, such as a concentration of elemental fluorine (F2), in particular equal to much higher than 15 vol% or even 20 vol% (i.e., at least 15 vol% or even 20 vol%), and to a process for producing fluorinated compounds by direct fluorination using a fluorination gas. The process of the present invention relates to the manufacture of fluorinated compounds other than fluorinated benzene by direct fluorination, in particular to the preparation of fluorinated organic compounds, end products and intermediates for use in agricultural, pharmaceutical, electronic, catalyst, solvent and other functional chemical applications. The fluorination process of the invention can be carried outin batches or in a continuous manner. If the process of the invention is carried out in batches, a column (tower) reactor may be used. If the process of the invention is continuous, a microreactor may be used.

Compounds, Compositions and Methods

Certain substituted urea derivatives modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Elemental fluorine. Part 20. Direct fluorination of deactivated aromatic systems using microreactor techniques

Continuous flow microreactor technology has been used for the direct fluorination of a range of deactivated di- and tri-substituted aromatic systems.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

COMPOUNDS, COMPOSITIONS AND METHODS

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Compounds, compositions and methods

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes

A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)- 4-pyrazolyl]-1-trans-propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor acti

Pyrazole derivatives

The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.