7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Base Information

Chemical Name:7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
CAS No.:1400653-04-4
Molecular Formula:C₁₇H₁₃BrF₄N₂O₃S
Molecular Weight:481.265
Hs Code.:

Synonyms:7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

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Chemical Property of 7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Chemical Property:

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Technology Process of 7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

There total 3 articles about 7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1400653-03-3
7-bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonyl chloride

: 371-40-4
4-fluoroaniline

: 1400653-04-4
7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: With pyridine; dmap; In chloroform; at 20 ℃; for 3h;
DOI:10.3987/COM-15-13387

Reference yield:

: 17680-55-6
7-bromo-1,2,3,4-tetrahydroisoquinoline

: 1400653-04-4
7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / chloroform / 20 h / 20 °C / Cooling with ice

2: chlorosulfonic acid / chloroform / 5 h / 20 - 60 °C / Cooling with ice

3: pyridine / chloroform / 13 h / 20 °C / Cooling with ice

With pyridine; chlorosulfonic acid; dmap; In chloroform;

Reference yield:

: 181514-35-2
1-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one

: 1400653-04-4
7-bromo-N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / chloroform / 5 h / 20 - 60 °C / Cooling with ice

2: pyridine / chloroform / 13 h / 20 °C / Cooling with ice

With pyridine; chlorosulfonic acid; In chloroform;