methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate

Base Information

• Chemical Name: methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate
• CAS No.: 251456-88-9
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 251456-88-9.mol

Synonyms:methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate

Chemical Property of methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate

There total 1 articles about methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

p-N,N-dimethylaminobenzoic acid (619-84-1) + methyl 4-(aminomethyl)benzoate hydrochloride (6232-11-7) → methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate (251456-88-9)

Guidance literature:

With TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane;

DOI:10.1021/jm991091h

Reference yield:

methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate (251456-88-9) → 4-(4-(N,N-dimethylamino)benzamidomethyl)benzoic acid (251456-72-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jm991091h

Reference yield:

methyl 4-(4-dimethylaminobenzoyl)aminomethylbenzoate (251456-88-9) → C17H19N3O3

Guidance literature:

Multi-step reaction with 3 steps

1: 1M aq. LiOH / tetrahydrofuran / 4 h / 20 °C

2: TEA; BOP-Cl / CH₂Cl₂

3: 34 percent / TBAF*3H₂O / tetrahydrofuran / 4 h / 20 °C

With lithium hydroxide; TEA; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; dichloromethane; 1: Hydrolysis / 2: Condensation / 3: desililation;

DOI:10.1021/jm991091h

upstream raw materials:

p-N,N-dimethylaminobenzoic acid

methyl 4-(aminomethyl)benzoate hydrochloride

Downstream raw materials:

4-(4-(N,N-dimethylamino)benzamidomethyl)benzoic acid

N-tert-butyldimethylsilyloxy-4-(4-dimethylaminobenzoyl)aminomethylbenzamide

Refernces